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Where are the New Targets in Severe Asthma? Looking Upstream in the Inflammatory Cascade

October 17, 2021 from 5:15 pm - 6:15 pm CDT

Sponsored by an educational grant from AstraZeneca Pharmaceuticals.


Program Description

Learn about a new paradigm of severe asthma pathophysiology and potential treatment targets that may impact patients with non-allergic and non-eosinophilic as well as eosinophilic severe asthma. The characterization of the alarmins and development of biologics that block their activity represent exciting advances for a broad group of patients. Meanwhile, basic science and clinical research continue to fuel the development of other agents that target different mediators of airway inflammation in asthma. Clinicians should be able to apply their knowledge of these advances as they strive to improve outcomes for individuals with severe asthma in their own practices. The symposium includes animations on pathophysiology to convey new concepts, and patient cases to apply strategies for treating severe asthma.

Learning Objectives:
Upon completion of this activity, the participant will be better able to:
1. Define the epithelial alarmins and their pivotal role in inflammation in asthma.
2. Describe how the epithelial alarmins impact both T2 and non-T2 downstream inflammation in asthma.
3. Explain how therapies, such as anti-TSLP, would be expected to modulate airway inflammation in patients with either a T2-high or T2-low phenotype.
4. Evaluate the results of clinical trials of novel therapies that target the epithelial alarmins.

Accreditation and Designation Statements:
Physicians: National Jewish Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

National Jewish Health designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This symposium is not supported, endorsed, or accredited by the American College of Chest Physicians.


Eileen Wang, MD, MPH
Assistant Professor
Division of Allergy & Clinical Immunology
Department of Medicine
National Jewish Health
Denver, CO

Michael E. Wechsler, MD, MMSc
Director of The Cohen Family Asthma Institute
Professor of Medicine
Division of Pulmonary, Critical Care, and Sleep Medicine
Department of Medicine
National Jewish Health
Denver, CO


National Jewish Health Office of Professional Education, [email protected]
Associated URL links: https://www.nationaljewish.org/asthmachest21


October 17, 2021
5:15 pm - 6:15 pm CDT
Event Category:

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